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Potential Roles of Adropin in Central Nervous System: Review of Current Literature


Potential Roles of Adropin in Central Nervous System: Review of Current Literature

Shima Shahjouei et al. Front Mol Biosci.


Adropin is a 4.9 kDa peptide that is important for maintenance of metabolic and non-metabolic homeostasis. It regulates glucose and fatty acid metabolism and is involved in endothelial cell function and endothelial nitric oxide (NO) synthase bioactivity as well as physical activity and motor coordination. Adropin is expressed in many tissues and organs including central nervous system (CNS). This peptide plays a crucial role in the development of various CNS disorders such as stroke, schizophrenia, bipolar disorder as well as Alzheimer's, Parkinson's, and Huntington's diseases. In this comprehensive review, the potential roles of adropin in cellular signaling pathways that lead to pathogenesis and/or treatment of CNS disorders will be discussed.

Keywords: adropin; biomarker; cellular signaling pathways; neurodegenerative disease; neuroprotection; predictor; therapeutic.


Figure 1
Figure 1
Schematic presentation of adropin signaling pathways. PDH, pyruvate dehydrogenase; PDK-4, pyruvate dehydrogenase kinase-4; HIF-1, hypoxia-inducible factor-1a; NB3, neural recognition molecule 3; VEGF, vascular endothelial growth factor; mhtt, mutant huntingtin; VEGFR2, vascular endothelial growth factor receptor 2; PI3K, phosphatidylinositol-3 kinase; Akt (Ser-473), phosphorylation of serine 473 of serine, threonine kinase; GS3Kβ, glycogen synthase kinase 3β; CD36, Cluster of Differentiation36; ERK 1/2, extracellular signal-regulated kinases 1/2; Mtor, mammalian target of rapamycin; BAD, Bcl-2 associated death protein; eNOS (Ser-1177), phosphorylation of endothelial nitric synthase on serine 1177; BNDF, brain-derived neurotrophic factor; FOXO, Forkhead box O; Bcl-2: B-cell lymphoma 2; Bax, Bcl-2 associated X protein; ROCK, Rho-associated protein kinase; MLC2-P, Phosphorylated myosin light chain 2.

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