Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease

Genomics. 1989 May;4(4):552-9. doi: 10.1016/0888-7543(89)90279-6.


Monoamine oxidase A and B (MAO A and B) are the central enzymes that catalyze oxidative deamination of biogenic amines throughout the body. The regional locations of genes encoding MAO A and B on the X chromosome were determined by using full-length cDNA clones for human MAO A and B, respectively. Using somatic cell hybrids, in situ hybridization, and field-inversion gel electrophoresis as well as deletion mapping in a patient with Norrie disease, we concluded that these two genes are close to each other and to the DXS7 locus (Xp 11.3).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blindness / enzymology
  • Blindness / genetics*
  • Chromosome Deletion*
  • Chromosome Mapping
  • DNA / genetics
  • Humans
  • Hybrid Cells
  • Male
  • Mice
  • Monoamine Oxidase / genetics*
  • Restriction Mapping
  • Retina / abnormalities*
  • X Chromosome*


  • DNA
  • Monoamine Oxidase