Therapeutic value of citicoline in the treatment of glaucoma (computerized and automated perimetric investigation)

Int Ophthalmol. 1989 Jan;13(1-2):109-12. doi: 10.1007/BF02028649.


The favourable neurotrophic effects obtained by means of the intramuscular administration of citicoline, one of the intermediate compounds of phospholipids, on the visual field of patients suffering from open-angle glaucoma are referred. The drug was administered at the dose of 1 gm for ten consecutive days. Visual field was examined by means of central computerized perimetry and automated perimetry. All patients had well controlled intraocular pressure through beta-blockers, but presented characteristic glaucomatous perimetric defects. It is suggested that citicoline might be administered as a useful complement to conventional hypotensive therapy, since it acts positively on the glaucomatous optic nerve damage.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Choline / analogs & derivatives*
  • Cytidine Diphosphate Choline / pharmacology*
  • Glaucoma, Open-Angle / drug therapy*
  • Humans
  • Middle Aged
  • Scotoma / complications
  • Time Factors
  • Visual Field Tests
  • Visual Fields / drug effects*


  • Cytidine Diphosphate Choline
  • Choline