Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders
- PMID: 27450033
- DOI: 10.1016/j.biopsych.2016.05.011
Excitation/Inhibition Imbalance in Animal Models of Autism Spectrum Disorders
Abstract
Imbalances between excitation and inhibition in synaptic transmission and neural circuits have been implicated in autism spectrum disorders. Excitation and inhibition imbalances are frequently observed in animal models of autism spectrum disorders, and their correction normalizes key autistic-like phenotypes in these animals. These results suggest that excitation and inhibition imbalances may contribute to the development and maintenance of autism spectrum disorders and represent an important therapeutic target.
Keywords: Autism spectrum disorders; Circuit; Excitation/inhibition balance; Mouse models; Psychiatric disorders; Synapse.
Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Similar articles
-
Microglia in the pathogenesis of autism spectrum disorders.Neurosci Res. 2015 Nov;100:1-5. doi: 10.1016/j.neures.2015.06.005. Epub 2015 Jun 25. Neurosci Res. 2015. PMID: 26116891 Review.
-
Ketogenic diet restores aberrant cortical motor maps and excitation-to-inhibition imbalance in the BTBR mouse model of autism spectrum disorder.Behav Brain Res. 2016 May 1;304:67-70. doi: 10.1016/j.bbr.2016.02.015. Epub 2016 Feb 11. Behav Brain Res. 2016. PMID: 26876011
-
Synaptic structural protein dysfunction leads to altered excitation inhibition ratios in models of autism spectrum disorder.Pharmacol Res. 2019 Jan;139:207-214. doi: 10.1016/j.phrs.2018.11.019. Epub 2018 Nov 19. Pharmacol Res. 2019. PMID: 30465851 Review.
-
Neurophysiology and Regulation of the Balance Between Excitation and Inhibition in Neocortical Circuits.Biol Psychiatry. 2017 May 15;81(10):821-831. doi: 10.1016/j.biopsych.2016.09.017. Epub 2016 Sep 29. Biol Psychiatry. 2017. PMID: 27865453 Free PMC article. Review.
-
Synaptopathology in autism spectrum disorders: Complex effects of synaptic genes on neural circuits.Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jun 8;84(Pt B):398-415. doi: 10.1016/j.pnpbp.2017.09.026. Epub 2017 Oct 3. Prog Neuropsychopharmacol Biol Psychiatry. 2018. PMID: 28986278 Review. No abstract available.
Cited by
-
Lowered ratio of corticospinal excitation to inhibition predicts greater disability, poorer motor and cognitive function in multiple sclerosis.Heliyon. 2024 Aug 6;10(15):e35834. doi: 10.1016/j.heliyon.2024.e35834. eCollection 2024 Aug 15. Heliyon. 2024. PMID: 39170378 Free PMC article.
-
Local and Interregional Neurochemical Associations Measured by Magnetic Resonance Spectroscopy for Studying Brain Functions and Psychiatric Disorders.Front Psychiatry. 2020 Aug 11;11:802. doi: 10.3389/fpsyt.2020.00802. eCollection 2020. Front Psychiatry. 2020. PMID: 32848957 Free PMC article. Review.
-
Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences.Mol Autism. 2020 Jul 27;11(1):62. doi: 10.1186/s13229-020-00358-x. Mol Autism. 2020. PMID: 32718349 Free PMC article.
-
Region-specific brain area reductions and increased cholecystokinin positive neurons in diabetic OLETF rats: implication for anxiety-like behavior.J Physiol Sci. 2020 Sep 16;70(1):42. doi: 10.1186/s12576-020-00771-0. J Physiol Sci. 2020. PMID: 32938363 Free PMC article.
-
Neuronal Splicing Regulator RBFOX3 (NeuN) Regulates Adult Hippocampal Neurogenesis and Synaptogenesis.PLoS One. 2016 Oct 4;11(10):e0164164. doi: 10.1371/journal.pone.0164164. eCollection 2016. PLoS One. 2016. PMID: 27701470 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
