Research that Guides Clinical Decisions

Mary-Margaret Chren; Sarah T Arron

doi:10.1016/j.jid.2016.04.031

Research that Guides Clinical Decisions

J Invest Dermatol. 2016 Aug;136(8):1535-1537. doi: 10.1016/j.jid.2016.04.031.

Authors

Mary-Margaret Chren¹, Sarah T Arron²

Affiliations

¹ Program for Clinical Research, Department of Dermatology, University of California, San Francisco, California, USA; Dermatology Service, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA. Electronic address: chrenm@derm.ucsf.edu.
² Program for Clinical Research, Department of Dermatology, University of California, San Francisco, California, USA; Dermatology Service, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.

PMID: 27450497
DOI: 10.1016/j.jid.2016.04.031

Abstract

The centerpiece of evidence-based medicine is the randomized controlled trial, a rigorous experiment. We use the study by Roozeboom et al. to illustrate how research guides clinical decisions. We describe levels of evidence, review criteria for assessing a trial regarding noninferiority of a therapy, and discuss challenges for evidence-based medicine in guiding care precisely targeted to an individual patient.

Publication types

Comment

MeSH terms

Evidence-Based Medicine*
Humans

Grants and funding

K24 AR052667/AR/NIAMS NIH HHS/United States