PICSAR: Long Noncoding RNA in Cutaneous Squamous Cell Carcinoma

J Invest Dermatol. 2016 Aug;136(8):1541-1542. doi: 10.1016/j.jid.2016.04.013.


It is increasingly evident that long noncoding RNAs may play the roles of both oncogenes and tumor suppressors during cancer development. A new study from Piipponen et al. provides evidence that a long noncoding RNA, PICSAR, promotes cutaneous squamous cell carcinoma development through activation of extracellular signal-regulated kinase signaling. Because specific inhibition of PICSAR suppresses tumor growth, this long noncoding RNA may serve as a useful diagnostic marker and therapeutic target for cutaneous squamous cell carcinoma.

Publication types

  • Comment

MeSH terms

  • Carcinoma, Squamous Cell / genetics*
  • Extracellular Signal-Regulated MAP Kinases
  • Humans
  • RNA, Long Noncoding / genetics*
  • Signal Transduction
  • Skin Neoplasms


  • RNA, Long Noncoding
  • Extracellular Signal-Regulated MAP Kinases