The Effects of Folate Supplementation on Carotid Intima-Media Thickness and Metabolic Status in Patients with Metabolic Syndrome

Ann Nutr Metab. 2016;69(1):41-50. doi: 10.1159/000448295. Epub 2016 Jul 23.

Abstract

Background: This study was carried out to evaluate the effects of folate supplementation on carotid intima-media thickness (CIMT) and metabolic status among patients with metabolic syndrome (MetS).

Methods: This randomized, double-blind, placebo-controlled trial was conducted among 60 patients with type 2 diabetes mellitus and coronary heart disease. They were all overweight in the age range 40-85 years. Participants were randomly divided into 2 groups: group A (n = 30) received 5 mg folate supplements and group B (n = 30) received placebo for 12 weeks.

Results: Folate supplementation resulted in a significant reduction in maximum levels of left CIMT (-0.05 ± 0.13 vs. +0.02 ± 0.11 mm, p = 0.01) compared with the placebo. Changes in fasting plasma glucose (-2.2 ± 37.5 vs. +30.2 ± 65.8 mg/dl, p = 0.02), serum insulin concentration (-2.0 ± 10.7 vs. +3.0 ± 7.6 µIU/ml, p = 0.04) and homeostasis of assessment-estimated insulin resistance (-0.6 ± 2.3 vs. +0.9 ± 2.3, p = 0.01) in supplemented patients were significantly different from those of patients in the placebo group. Changes in serum triglycerides (p = 0.04), high-density lipoprotein-cholesterol (p = 0.001), high sensitivity C-reactive protein (p = 0.01) and plasma nitric oxide concentrations (p < 0.001) were significantly different between the supplemented patients and placebo group.

Conclusions: Overall, 5 mg/day folate supplementation for 12 weeks among patients with MetS had beneficial effects on CIMT and the metabolic status.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Glucose / drug effects
  • Carotid Intima-Media Thickness*
  • Cholesterol, HDL / blood
  • Coronary Disease / complications
  • Coronary Disease / prevention & control
  • Diabetes Mellitus, Type 2*
  • Dietary Supplements*
  • Double-Blind Method
  • Female
  • Folic Acid / administration & dosage*
  • Folic Acid / pharmacology
  • Folic Acid / therapeutic use
  • Humans
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / diagnostic imaging
  • Metabolic Syndrome / diet therapy*
  • Metabolic Syndrome / metabolism
  • Middle Aged
  • Obesity*
  • Treatment Outcome
  • Triglycerides / blood

Substances

  • Blood Glucose
  • Cholesterol, HDL
  • Triglycerides
  • Folic Acid

Associated data

  • IRCT/IRCT201503175623N40