Genomic correction of familial cardiomyopathy in human engineered cardiac tissues

Eur Heart J. 2016 Nov 14;37(43):3282-3284. doi: 10.1093/eurheartj/ehw307. Epub 2016 Jul 22.


In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.

Keywords: Dilated cardiomyopathy; Engineered heart tissue; Gene editing; Induced pluripotent stem cells; Phospholamban.

MeSH terms

  • Calcium-Binding Proteins
  • Cardiomyopathies*
  • Genomics
  • Humans
  • Mutation


  • Calcium-Binding Proteins