Thymosin β4 Promotes Dermal Healing

Vitam Horm. 2016:102:251-75. doi: 10.1016/bs.vh.2016.04.005. Epub 2016 May 24.

Abstract

No agent has been identified that significantly accelerates the repair of chronic dermal wounds in humans. Thymosin beta 4 (Tβ4) is a small, abundant, naturally occurring regenerative protein that is found in body fluids and inside cells. It was found to have angiogenic and antiinflammatory activity and to be high in platelets that aggregate at the wound site. Thus we used Tβ4 initially in dermal healing. It has since been shown to have many activities important in tissue protection, repair, and regeneration. Tβ4 increases the rate of dermal healing in various preclinical animal models, including diabetic and aged animals, and is active for burns as well. Tβ4 also accelerated the rate of repair in phase 2 trials with patients having pressure ulcers, stasis ulcers, and epidermolysis bullosa wounds. It is safe and well tolerated and will likely have additional uses in the skin and in injured organs for tissue repair and regeneration.

Keywords: Angiogenesis; Antiapoptotic; Antifibrotic; Antiinflammatory; Dermal healing; Regeneration; Stem cells; Thymosin beta 4.

Publication types

  • Review

MeSH terms

  • Animals
  • Burns / drug therapy
  • Burns / physiopathology
  • Catalytic Domain
  • Clinical Trials, Phase I as Topic
  • Clinical Trials, Phase II as Topic
  • Humans
  • Receptors, Immunologic
  • Skin / injuries*
  • Thymosin / adverse effects
  • Thymosin / physiology*
  • Thymosin / therapeutic use
  • Wound Healing* / physiology

Substances

  • Receptors, Immunologic
  • thymosin receptor
  • thymosin beta(4)
  • Thymosin