Uranium concentrations were radiochemically determined in samples of lung, kidney, liver and bone collected at autopsy from an occupationally exposed individual. Levels of U in these tissues were clearly in excess of those expected from environmental exposure. Deposition followed the pattern: skeleton greater than liver greater than kidney, with ratios of 63:2.8:1. The data suggest there is an important long-term storage depot in the skeleton, but the fraction transferred to this compartment, as proposed by ICRP 30, may be too small. In vivo chest counts obtained over about a 10-y period prior to death indicated about a factor of 2 greater in total U content and 235U enrichment than deposition estimates made at autopsy for the lungs and associated lymph nodes.