Ending preventable maternal and newborn deaths due to infection

Best Pract Res Clin Obstet Gynaecol. 2016 Oct;36:116-130. doi: 10.1016/j.bpobgyn.2016.05.008. Epub 2016 Jun 23.

Abstract

Over 300,000 maternal deaths occur each year, 11% of which are thought to be due to infectious causes, and approximately one million newborns die within the first week of life annually due to infectious causes. Infections in pregnancy may result in a variety of adverse obstetrical outcomes, including preterm delivery, pre-labor rupture of membranes, stillbirth, spontaneous abortion, congenital infection, and anomalies. This paper reviews the burden of disease due to key infections and their contribution to maternal, perinatal, and newborn morbidity and mortality, as well as key interventions to prevent maternal and newborn deaths related to these infections. Research needs include more accurate clinical and microbiologic surveillance systems, validated risk stratification strategies, better point-of-care testing, and identification of promising vaccine strategies.

Keywords: HIV; malaria; maternal sepsis; neonatal sepsis; respiratory syncytial virus; syphilis.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Antimalarials / therapeutic use
  • Antitubercular Agents / therapeutic use
  • Female
  • HIV Infections / complications
  • HIV Infections / diagnosis
  • HIV Infections / drug therapy*
  • Humans
  • Infant, Newborn
  • Malaria / drug therapy
  • Malaria / prevention & control
  • Mass Screening
  • Maternal Death / etiology
  • Maternal Death / prevention & control*
  • Neonatal Sepsis / complications
  • Neonatal Sepsis / prevention & control*
  • Neonatal Sepsis / therapy
  • Perinatal Death / etiology
  • Perinatal Death / prevention & control*
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy
  • Pregnancy Complications, Infectious / prevention & control*
  • Sepsis / complications
  • Sepsis / prevention & control*
  • Sepsis / therapy
  • Streptococcal Infections / complications
  • Streptococcal Infections / drug therapy*
  • Streptococcal Infections / prevention & control
  • Streptococcus agalactiae
  • Syphilis / complications
  • Syphilis / diagnosis
  • Syphilis / drug therapy
  • Tuberculosis / complications
  • Tuberculosis / diagnosis
  • Tuberculosis / drug therapy

Substances

  • Anti-Bacterial Agents
  • Antimalarials
  • Antitubercular Agents