Cardiovascular risk of BRCA1/2 mutation carriers: A review

Maturitas. 2016 Sep:91:135-9. doi: 10.1016/j.maturitas.2016.06.012. Epub 2016 Jun 22.


BRCA1/2 mutation carriers are at high risk of breast and ovarian cancer. The number of studies on non-cancer endpoints in BRCA1/2 mutation carriers is still limited. BRCA1/2 mutation carriers may be at higher cardiovascular risk due to early menopause after risk-reducing salpingo-oophorectomy and/or due to the potential cardiotoxic effects of breast cancer treatment (radiotherapy and chemotherapy). Moreover, BRCA genes have a role as a gatekeeper in cardiac function and structure, which may affect susceptibility to cardiac damage. Our goal is to review current knowledge of cardiovascular risk among BRCA1/2 mutation carriers.

Keywords: BRCA; Cardio-oncology; Cardiotoxicity; Cardiovascular disease; Salpingo-oophorectomy.

Publication types

  • Review

MeSH terms

  • BRCA1 Protein / genetics*
  • BRCA2 Protein / genetics*
  • Breast Neoplasms / complications
  • Breast Neoplasms / genetics*
  • Cardiovascular Diseases / epidemiology*
  • Cardiovascular Diseases / genetics
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Mutation
  • Risk Factors
  • Risk Reduction Behavior
  • Women's Health


  • BRCA1 Protein
  • BRCA2 Protein