ATXN2 polymorphism modulates age at onset in Machado-Joseph disease

Brain. 2016 Oct 1;139(10):e59. doi: 10.1093/brain/aww176.

Authors

Dongxue Ding¹, Kai Li¹, Chunrong Wang¹, Zhao Chen¹, Zhe Long¹, Yun Peng¹, Xin Zhou¹, Huirong Peng¹, Rong Qiu², Kun Xia³, Beisha Tang^{1

3

4}, Hong Jiang^{1

3

4

5}

Affiliations

¹ 1 Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
² 2 School of Information Science and Engineering, Central South University, Changsha, China.
³ 3 State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, P.R. China.
⁴ 4 Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, P.R. China.
⁵ 5 Xinjiang Medical University, Xinjiang, 830011, P.R. China.

PMID: 27452601
DOI: 10.1093/brain/aww176

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Age of Onset
Ataxin-2 / genetics*
Child
China / epidemiology
Female
Humans
Machado-Joseph Disease / diagnosis
Machado-Joseph Disease / epidemiology*
Machado-Joseph Disease / genetics*
Male
Middle Aged
Polymorphism, Genetic / genetics*
Young Adult

Substances

ATXN2 protein, human
Ataxin-2