How sesquiterpenes modulate signaling cascades in cancers

Cell Mol Biol (Noisy-le-grand). 2016 Jun 30;62(7):110-7.

Abstract

Data obtained from high-throughput technologies has started to shed light on the interplay between signal transduction cascades and chromatin modifications thus adding another layer of complexity to the already complex regulation of the protein network. Based on the insights gleaned from almost a decade of research, it has now been convincingly revealed that sesquiterpenes effectively modulated different intracellular signaling cascades in different cancers. In this review we summarize how sesquiterpenes mediated Wnt, Shh, Notch and TRAIL induced signaling cascades.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Drug Resistance, Neoplasm / drug effects
  • Humans
  • Neoplasm Proteins / metabolism
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Sesquiterpenes / pharmacology
  • Sesquiterpenes / therapeutic use*
  • Signal Transduction* / drug effects

Substances

  • Neoplasm Proteins
  • Sesquiterpenes