In 1999, Hahnfeldt et al. proposed a mathematical model for tumor growth as dictated by reciprocal communications between tumor and its associated vasculature, introducing the idea that a tumor is supported by a dynamic, rather than a static, carrying capacity. In this original paper, the carrying capacity was equated with the variable tumor vascular support resulting from the net effect of tumor-derived angiogenesis stimulators and inhibitors. This dynamic carrying capacity model was further abstracted and developed in our recent publication to depict the more general situation where there is an interaction between the tumor and its supportive host tissue; in that case, as a function of host aging (Benzekry et al., 2014). This allowed us to predict a range of host changes that may be occurring with age that impact tumor dynamics. More generally, the basic formalism described here can be (and has been), extended to the therapeutic context using additional optimization criteria (Hahnfeldt et al., 1999). The model depends on three parameters: One for the tumor cell proliferation kinetics, one for the stimulation of the stromal support, and one for its inhibition, as well as two initial conditions. We describe here the numerical method to estimate these parameters from longitudinal tumor volume measurements.
Critical reflections on the currently leading definition of sustainable employability.Scand J Work Environ Health. 2016 Jun 1;42(6):557-560. doi: 10.5271/sjweh.3585. Epub 2016 Aug 22. Scand J Work Environ Health. 2016. PMID: 27548816
Macromolecular crowding: chemistry and physics meet biology (Ascona, Switzerland, 10-14 June 2012).Phys Biol. 2013 Aug;10(4):040301. doi: 10.1088/1478-3975/10/4/040301. Epub 2013 Aug 2. Phys Biol. 2013. PMID: 23912807
New approach to modeling of antiangiogenic treatment on the basis of Hahnfeldt et al. model.Math Biosci Eng. 2011 Apr;8(2):591-603. doi: 10.3934/mbe.2011.8.591. Math Biosci Eng. 2011. PMID: 21631148
Thymic commitment of regulatory T cells is a pathway of TCR-dependent selection that isolates repertoires undergoing positive or negative selection.Curr Top Microbiol Immunol. 2005;293:43-71. doi: 10.1007/3-540-27702-1_3. Curr Top Microbiol Immunol. 2005. PMID: 15981475 Review.
Transforming growth factor-beta system and its regulation by members of the steroid-thyroid hormone superfamily.Adv Cancer Res. 1996;70:63-94. doi: 10.1016/s0065-230x(08)60872-6. Adv Cancer Res. 1996. PMID: 8902054 Review.