Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders

doi:10.1016/j.dadm.2016.05.005

Review

. 2016 Jun 25:3:98-102.

doi: 10.1016/j.dadm.2016.05.005. eCollection 2016.

Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders

Ulf Andreasson¹, Kaj Blennow¹, Henrik Zetterberg²

Affiliations

¹ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
² Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.

PMID: 27453931
PMCID: PMC4941042
DOI: 10.1016/j.dadm.2016.05.005

Free PMC article

Review

Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders

Ulf Andreasson et al. Alzheimers Dement (Amst). 2016.

Free PMC article

. 2016 Jun 25:3:98-102.

doi: 10.1016/j.dadm.2016.05.005. eCollection 2016.

Authors

Ulf Andreasson¹, Kaj Blennow¹, Henrik Zetterberg²

Affiliations

¹ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
² Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK.

PMID: 27453931
PMCID: PMC4941042
DOI: 10.1016/j.dadm.2016.05.005

Abstract

Most research on fluid biomarkers for central nervous system (CNS) disorders has so far been performed using cerebrospinal fluid (CSF) as the biomarker source. CSF has the advantage of being closer to the brain than serum or plasma with a relative enrichment of CNS-specific proteins that are present at very low concentrations in the blood and thus difficult to reliably quantify using standard immunochemical technologies. Recent technical breakthroughs in the field of ultrasensitive assays have started to change this. Here, we review the most established ultrasensitive quantitative technologies that are currently available to general biomarker laboratories and discuss their use in research on biomarkers for CNS disorders.

Keywords: Alzheimer's disease; Biomarkers; Blood; Central nervous system; Plasma; Serum; Ultrasensitive.

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References

1. Brinkmalm A., Portelius E., Ohrfelt A., Brinkmalm G., Andreasson U., Gobom J. Explorative and targeted neuroproteomics in Alzheimer's disease. Biochim Biophys Acta. 2015;1854:769–778. - PubMed
1. Florentinus-Mefailoski A., Safi F., Marshall J.G. Enzyme linked immuno mass spectrometric assay (ELIMSA) J Proteomics. 2014;96:343–352. - PubMed
1. Berlyand Y., Weintraub D., Xie S.X., Mellis I.A., Doshi J., Rick J. An Alzheimer's Disease-Derived Biomarker Signature Identifies Parkinson's Disease Patients with Dementia. PLoS One. 2016;11:e0147319. - PMC - PubMed
1. Chen A., Oakley A.E., Monteiro M., Tuomela K., Allan L.M., Mukaetova-Ladinska E.B. Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias. Neurobiol Aging. 2016;38:56–67. - PMC - PubMed
1. Uhlen M., Fagerberg L., Hallstrom B.M., Lindskog C., Oksvold P., Mardinoglu A. Proteomics. Tissue-based map of the human proteome. Science. 2015;347:1260419. - PubMed

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[1] Brinkmalm A., Portelius E., Ohrfelt A., Brinkmalm G., Andreasson U., Gobom J. Explorative and targeted neuroproteomics in Alzheimer's disease. Biochim Biophys Acta. 2015;1854:769–778. - PubMed

[2] Brinkmalm A., Portelius E., Ohrfelt A., Brinkmalm G., Andreasson U., Gobom J. Explorative and targeted neuroproteomics in Alzheimer's disease. Biochim Biophys Acta. 2015;1854:769–778. - PubMed

[3] Florentinus-Mefailoski A., Safi F., Marshall J.G. Enzyme linked immuno mass spectrometric assay (ELIMSA) J Proteomics. 2014;96:343–352. - PubMed

[4] Florentinus-Mefailoski A., Safi F., Marshall J.G. Enzyme linked immuno mass spectrometric assay (ELIMSA) J Proteomics. 2014;96:343–352. - PubMed

[5] Berlyand Y., Weintraub D., Xie S.X., Mellis I.A., Doshi J., Rick J. An Alzheimer's Disease-Derived Biomarker Signature Identifies Parkinson's Disease Patients with Dementia. PLoS One. 2016;11:e0147319. - PMC - PubMed

[6] Berlyand Y., Weintraub D., Xie S.X., Mellis I.A., Doshi J., Rick J. An Alzheimer's Disease-Derived Biomarker Signature Identifies Parkinson's Disease Patients with Dementia. PLoS One. 2016;11:e0147319. - PMC - PubMed

[7] Chen A., Oakley A.E., Monteiro M., Tuomela K., Allan L.M., Mukaetova-Ladinska E.B. Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias. Neurobiol Aging. 2016;38:56–67. - PMC - PubMed

[8] Chen A., Oakley A.E., Monteiro M., Tuomela K., Allan L.M., Mukaetova-Ladinska E.B. Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias. Neurobiol Aging. 2016;38:56–67. - PMC - PubMed

[9] Uhlen M., Fagerberg L., Hallstrom B.M., Lindskog C., Oksvold P., Mardinoglu A. Proteomics. Tissue-based map of the human proteome. Science. 2015;347:1260419. - PubMed

[10] Uhlen M., Fagerberg L., Hallstrom B.M., Lindskog C., Oksvold P., Mardinoglu A. Proteomics. Tissue-based map of the human proteome. Science. 2015;347:1260419. - PubMed

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Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders

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Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders

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