Resting-state functional MR imaging shed insights into the brain of diabetes

Metab Brain Dis. 2016 Oct;31(5):993-1002. doi: 10.1007/s11011-016-9872-4. Epub 2016 Jul 26.


Diabetes mellitus is a common metabolic disease which is associated with increasing risk for multiple cognitive declines. Alterations in brain functional connectivity are believed to be the mechanisms underlying the cognitive function impairments. During the past decade, resting-state functional magnetic resonance imaging (rs-fMRI) has been developed as a major tool to study brain functional connectivity in vivo. This paper briefly reviews the diabetes-associated cognitive impairment, analysis algorithms and clinical applications of rs-fMRI. We also provide future perspectives of rs-fMRI in diabetes.

Keywords: Cognition disorders; Diabetes mellitus; Magnetic resonance imaging; Type 1 diabetes mellitus; Type 2 diabetes mellitus.

Publication types

  • Review

MeSH terms

  • Brain / diagnostic imaging*
  • Brain / metabolism
  • Diabetes Mellitus / diagnostic imaging*
  • Diabetes Mellitus / metabolism
  • Diabetic Neuropathies / diagnostic imaging
  • Diabetic Neuropathies / metabolism
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Rest* / physiology