The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials

Obes Rev. 2016 Dec;17(12):1329-1340. doi: 10.1111/obr.12458. Epub 2016 Jul 26.


Background: Potential effects of resveratrol consumption on cardiovascular disease risk factors and body weight in overweight/obese adults have not been fully elucidated. Our present analysis was to evaluate the effects of resveratrol consumption on risk markers related to cardiovascular health in overweight/obese Individuals.

Methods: Multiple literature databases were systematically searched, and 21 studies were included. Effect sizes were expressed as weighted mean difference (WMD) and 95% confidence interval (CI), and heterogeneity was assessed with the I2 test. Publication bias and subgroup analyses were also performed.

Results: There were variations in reporting quality of included studies. Resveratrol intervention significantly lowered total cholesterol (WMD, -0.19 mmol/L; 95% CI, -0.32 to -0.06; P = 0.004), systolic blood pressure (WMD, -2.26 mmHg; 95% CI, -4.82 to -0.49; P = 0.02), and fasting glucose (WMD, -0.22 mmol/L; 95% CI, -0.42 to -0.03; P = 0.03). Heterogeneity was noted for these outcomes (35.6%, 38.7% and 71.4%, respectively). Our subgroup analysis showed significant reductions in total cholesterol, systolic blood pressure, diastolic blood pressure, glucose, and insulin in subjects ingesting higher dose of resveratrol (≥300 mg/day).

Conclusion: Our finding provides evidence that daily resveratrol consumption might be a candidate as an adjunct to pharmacological management to better prevent and control cardiovascular disease in overweight/obese individuals.

Keywords: Cardiovascular risk factors; obesity; overweight; resveratrol.

Publication types

  • Review

MeSH terms

  • Biomarkers / blood
  • Blood Pressure / drug effects
  • Body Mass Index
  • Cardiovascular Diseases / drug therapy*
  • Cholesterol / blood
  • Humans
  • Insulin Resistance
  • Meta-Analysis as Topic
  • Obesity / drug therapy*
  • Overweight / drug therapy*
  • Randomized Controlled Trials as Topic
  • Reproducibility of Results
  • Resveratrol
  • Risk Factors
  • Stilbenes / administration & dosage*
  • Stilbenes / blood


  • Biomarkers
  • Stilbenes
  • Cholesterol
  • Resveratrol