Association of TLR polymorphisms with bronchopulmonary dysplasia

Gene. 2016 Oct 30;592(1):23-28. doi: 10.1016/j.gene.2016.07.049. Epub 2016 Jul 25.

Abstract

Bronchopulmonary dysplasia (BPD) remains a leading cause of morbidity and mortality during infancy. Evidence suggests that the Toll-like receptor (TLR) signaling pathway plays an integral role in lung inflammation and injury. This study aimed to detect single nucleotide polymorphisms (SNPs) in TLR pathway genes [TLR5 and Toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP)] among preterm neonates and to determine their association with the development and severity of bronchopulmonary dysplasia.

Keywords: Bronchopulmonary dysplasia; Neonatal mortality; Oxygen therapy; Preterm neonates; Sepsis; Toll-like receptors.

MeSH terms

  • Bronchopulmonary Dysplasia / genetics*
  • Bronchopulmonary Dysplasia / pathology
  • Case-Control Studies
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Membrane Glycoproteins / genetics*
  • Polymorphism, Single Nucleotide*
  • Receptors, Interleukin-1 / genetics*
  • Toll-Like Receptor 5 / genetics*

Substances

  • Membrane Glycoproteins
  • Receptors, Interleukin-1
  • TIRAP protein, human
  • TLR5 protein, human
  • Toll-Like Receptor 5