Characterization of Spectinomycin Resistance in Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6390-2. doi: 10.1128/AAC.01157-16. Print 2016 Oct.


Spectinomycin is an aminocyclitol antibiotic used clinically to treat a variety of infections in animals. Here, we characterized drug resistance prevalence in clinical Streptococcus suis isolates and discovered a novel resistance mechanism in which the s5 mutation (Gly26Asp) results in high spectinomycin resistance. Additionally, a novel integrative and conjugative element encompassing a multidrug resistance spw_like-aadE-lnu(B)-lsa(E) cluster and a cadmium resistance operon were identified, suggesting a possible cause for the wide dissemination of spectinomycin resistance in S. suis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Cadmium / pharmacology
  • China
  • Drug Resistance, Bacterial / drug effects
  • Drug Resistance, Bacterial / genetics*
  • Microbial Sensitivity Tests
  • Multigene Family
  • Mutation
  • Operon
  • RNA, Ribosomal, 16S
  • Ribosomal Proteins / genetics
  • Spectinomycin / pharmacology*
  • Streptococcus suis / drug effects*
  • Streptococcus suis / genetics
  • Streptococcus suis / isolation & purification


  • Anti-Bacterial Agents
  • Bacterial Proteins
  • RNA, Ribosomal, 16S
  • Ribosomal Proteins
  • Cadmium
  • Spectinomycin