Implications of the Bystander and Abscopal Effects of Radiation Therapy

Clin Cancer Res. 2016 Oct 1;22(19):4763-4765. doi: 10.1158/1078-0432.CCR-16-1512. Epub 2016 Jul 25.


Siva and colleagues have demonstrated that localized thoracic radiation resulted in DNA damage at out-of-field sites. Although these interesting findings require validation, we discuss the important clinical implications of these data, especially in the era of immune therapies. Clin Cancer Res; 22(19); 4763-5. ©2016 AACRSee related article by Siva et al., p. 4817.

Publication types

  • Comment

MeSH terms

  • Bystander Effect
  • Carcinoma, Non-Small-Cell Lung*
  • DNA Damage
  • Humans
  • Lung Neoplasms*