Microglia: Phagocytosing to Clear, Sculpt, and Eliminate

Dev Cell. 2016 Jul 25;38(2):126-8. doi: 10.1016/j.devcel.2016.07.006.


Microglia are the primary phagocytes of the central nervous system. They eliminate excess functional connections between neurons to sculpt neuronal circuits during development and throughout adulthood. Understanding how microglia recognize and prune synapses during development is providing insight into synapse loss and dysfunction in disease.

MeSH terms

  • Animals
  • Brain / physiology*
  • Humans
  • Microglia / physiology*
  • Neurons / physiology*
  • Phagocytosis / physiology*
  • Synapses / physiology*