A Case of Bullous Pemphigoid ınduced by Vildagliptin

Cutan Ocul Toxicol. 2017 Jun;36(2):201-202. doi: 10.1080/15569527.2016.1211670. Epub 2016 Aug 11.

Abstract

Bullous pemfigoid (BP), an autoimmune disorder, can also be induced by some medications. Vildagliptin is a new drug used to treat diabetes mellitus (DM). Recently, a few cases of vildagliptin-induced BP have been described in the literature. We report a patient with BP in which vildagliptin was thought to be as a possible causative agent. The awareness of BP development risk during gliptin therapy can prevent unnecessary usage of systemic drugs with serious side effects.

Keywords: Bullous pemphigoid; gliptins; vildagliptin.

Publication types

  • Case Reports

MeSH terms

  • Adamantane / adverse effects
  • Adamantane / analogs & derivatives*
  • Adamantane / therapeutic use
  • Administration, Cutaneous
  • Clobetasol / administration & dosage
  • Clobetasol / therapeutic use
  • Complement C3 / immunology
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Dipeptidyl-Peptidase IV Inhibitors / adverse effects*
  • Dipeptidyl-Peptidase IV Inhibitors / therapeutic use
  • Drug Eruptions / diagnosis*
  • Drug Eruptions / drug therapy
  • Drug Eruptions / immunology
  • Female
  • Fluorescent Antibody Technique
  • Gliclazide / therapeutic use
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / therapeutic use
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Metformin / therapeutic use
  • Middle Aged
  • Nitriles / adverse effects*
  • Nitriles / therapeutic use
  • Pemphigoid, Bullous / chemically induced*
  • Pemphigoid, Bullous / diagnosis
  • Pemphigoid, Bullous / drug therapy
  • Pemphigoid, Bullous / immunology
  • Pyrrolidines / adverse effects*
  • Pyrrolidines / therapeutic use
  • Skin / immunology
  • Skin / pathology
  • Vildagliptin
  • Withholding Treatment

Substances

  • Complement C3
  • Dipeptidyl-Peptidase IV Inhibitors
  • Glucocorticoids
  • Hypoglycemic Agents
  • Nitriles
  • Pyrrolidines
  • Metformin
  • Clobetasol
  • Gliclazide
  • Vildagliptin
  • Adamantane