Protective effect of ayurvedic formulations against doxorubicin-induced cardiotoxicity: Preliminary studies on Brahma Rasayana and Chyavanaprash

J Cancer Res Ther. Apr-Jun 2016;12(2):561-4. doi: 10.4103/0973-1482.151931.

Abstract

Aim of study: The present work aimed to examine the efficacy of two ayurvedic formulations, Brahma Rasayana (BRM) and Chyavanaprash (CHM) to alleviate doxorubicin (DOX) induced acute cardiotoxicity.

Materials and methods: Swiss albino mice were administered with DOX (25 mg/kg, i.p.) and two doses of BRM or CHM (1 and 2 g/kg). Cardiotoxicity was assessed by measuring the levels of various antioxidant parameters in the heart as well as release of marker enzymes in the serum was assayed. Histology of the heart was also performed to check for DOX-induced damages.

Results: Administration of either BRM or CHM (1 and 2 g/kg) maintained the antioxidant status in the heart thereby preventing tissue damage as well as the release of marker enzymes. DOX-induced variation of cardiac architecture was also prevented by BRM and CHM administration.

Conclusion: BRM and CHM administration could prevent DOX-induced acute cardiotoxicity.

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Cardiotoxicity / prevention & control
  • Doxorubicin / toxicity*
  • Lipid Peroxidation / drug effects
  • Male
  • Medicine, Ayurvedic*
  • Mice
  • Myocardium / pathology
  • Plant Extracts / pharmacology*
  • Plant Preparations / pharmacology*

Substances

  • Antioxidants
  • Chyavanprash
  • Plant Extracts
  • Plant Preparations
  • brahma rasayana
  • Doxorubicin