Discovery of a Potent and Selective Hetero-Bivalent AChE Inhibitor via Bioisosteric Replacement

Orazio Nicolotti; Leonardo Pisani; Marco Catto; Francesco Leonetti; Ilenia Giangreco; Angela Stefanachi; Angelo Carotti

doi:10.1002/minf.201000126

Discovery of a Potent and Selective Hetero-Bivalent AChE Inhibitor via Bioisosteric Replacement

Mol Inform. 2011 Mar 14;30(2-3):133-6. doi: 10.1002/minf.201000126. Epub 2011 Mar 18.

Authors

Orazio Nicolotti¹, Leonardo Pisani¹, Marco Catto¹, Francesco Leonetti¹, Ilenia Giangreco¹, Angela Stefanachi¹, Angelo Carotti²

Affiliations

¹ Dipartimento Farmaco-Chimico, Università degli Studi di Bari "Aldo Moro"via Orabona 4, 70125 Bari, Italy tel.: +39 080 5442782; fax: +39 080 5442230.
² Dipartimento Farmaco-Chimico, Università degli Studi di Bari "Aldo Moro"via Orabona 4, 70125 Bari, Italy tel.: +39 080 5442782; fax: +39 080 5442230. carotti@farmchim.uniba.it.

PMID: 27466764
DOI: 10.1002/minf.201000126

No abstract available

Keywords: Alzheimer’s disease; Bioisosteric replacement; Dual binding site AChE inhibitors; Selective hetero-bivalent acetylcholinesterase inhibitors.