Tetraspanin CD81, a modulator of immune suppression in cancer and metastasis

Oncoimmunology. 2015 Dec 18;5(5):e1120399. doi: 10.1080/2162402X.2015.1120399. eCollection 2016 May.


Cancer cells can escape the antitumor immune response by recruiting immune suppressor cells. However, although innate myeloid-derived suppressor cells (MDSCs) and T regulatory (Treg) cells accumulate normally in tumor-bearing CD81-deficient mice, both populations are impaired in their ability to suppress the antitumor immune response.

Keywords: CD81 knockout (CD81KO) mice; T regulatory (Treg) cells; myeloid-derived suppressor cells (MDSCs); tumor.

Publication types

  • Research Support, Non-U.S. Gov't