Orthobiologic Interventions Using Ultrasound Guidance

Phys Med Rehabil Clin N Am. 2016 Aug;27(3):717-31. doi: 10.1016/j.pmr.2016.04.007.


The application of regenerative therapies for the treatment of musculoskeletal conditions has emerged over the last decade with recent acceleration. These include prolotherapy, platelet-rich plasma, and mesenchymal stem cell therapy. These strategies augment the body's innate physiology to heal pathologic processes. This article presents an overview of platelet-rich plasma and mesenchymal stem cell therapy for the treatment of musculoskeletal injuries. A brief literature review is included, as are techniques for the use of ultrasound guidance to assist with these procedures.

Keywords: Biologic agents; Ligament; Muscle; Orthobiologics; Platelet-rich plasma; Regenerative medicine; Stem cell therapy; Tendon.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / transplantation
  • Chronic Disease
  • Femur Head Necrosis / therapy
  • Humans
  • Mesenchymal Stem Cell Transplantation / adverse effects
  • Mesenchymal Stem Cell Transplantation / methods*
  • Musculoskeletal Diseases / diagnostic imaging
  • Musculoskeletal Diseases / therapy*
  • Osteoarthritis / therapy
  • Platelet-Rich Plasma*
  • Tendinopathy / therapy
  • Tennis Elbow / therapy
  • Ultrasonography, Interventional / methods*
  • Wounds and Injuries / diagnostic imaging
  • Wounds and Injuries / therapy*