Mitochondrial replacement techniques: egg donation, genealogy and eugenics

Monash Bioeth Rev. 2016 Mar;34(1):37-51. doi: 10.1007/s40592-016-0059-x.

Abstract

Several objections against the morality of researching or employing mitochondrial replacement techniques have been advanced recently. In this paper, I examine three of these objections and show that they are found wanting. First I examine whether mitochondrial replacement techniques, research and clinical practice, should not be carried out because of possible harms to egg donors. Next I assess whether mitochondrial replacement techniques should be banned because they could affect the study of genealogical ancestry. Finally, I examine the claim that mitochondrial replacement techniques are not transferring mitochondrial DNA but nuclear DNA, and that this should be prohibited on ethical grounds.

Keywords: Maternal spindle transfer; Mitochondrial donation; Mitochondrial replacement techniques; Pronuclear transfer; Three parent IVF; Three parent babies; Tri-parenthood.

Publication types

  • Review

MeSH terms

  • Eugenics*
  • Female
  • Genealogy and Heraldry*
  • Humans
  • Male
  • Mitochondrial Replacement Therapy*
  • Reproductive Techniques, Assisted*
  • Tissue Donors*