Endocrine Disorders in Cystic Fibrosis

Pediatr Clin North Am. 2016 Aug;63(4):699-708. doi: 10.1016/j.pcl.2016.04.009.


Cystic fibrosis is frequently complicated by endocrine disorders. Diabetes can be expected to affect most with CF and pancreatic insufficiency and varies widely in age of onset, but early identification and treatment improve morbidity and mortality. Short stature can be exacerbated by relative delay of puberty and by use of inhaled corticosteroids. Bone disease in CF causes fragility fractures and should be assessed by monitoring bone mineral density and optimizing vitamin D status. Detecting and managing endocrine complications in CF can reduce morbidity and mortality in CF. These complications can be expected to become more common as the CF population ages.

Keywords: Diabetes; Hypoglycemia; Hypogonadism; Osteoporosis; Short stature.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cystic Fibrosis / complications*
  • Cystic Fibrosis / drug therapy
  • Endocrine System Diseases / diagnosis
  • Endocrine System Diseases / drug therapy
  • Endocrine System Diseases / etiology*
  • Female
  • Humans
  • Male