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, 67 (3), 415-423

The Effects of Two-Stage Carotid Occlusion on Spatial Memory and Pro-Inflammatory Markers in the Hippocampus of Rats

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The Effects of Two-Stage Carotid Occlusion on Spatial Memory and Pro-Inflammatory Markers in the Hippocampus of Rats

Mehrnoush Moghaddasi et al. J Physiol Sci.

Abstract

The purpose of this study was to evaluate the effects of cerebral hypoperfusion on cognitive ability, TNFα, IL1β and PGE2 levels in both hippocampi in a modified two-vessel occlusion model. Both common carotid arteries of adult male Wistar rats were permanently occluded with an interval of 1 week between occlusions. Learning and memory were significantly decreased after 1 month. This reduction was not significant after 2 months, which may be attributed to blood flow compensation. The TNFα level was significantly increased after 3 h and 1 day. IL1β was significantly increased after 1 day. After a week there was no significant difference in pro-inflammatory levels. Furthermore, there was no difference between right and left hippocampi. It is possible that TNFα and IL1β elevation initiates pathologic processes that contribute to memory impairment.

Keywords: Cerebral hypoperfusion; Hippocampus; Inflammation; Interleukins; Spatial memory.

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