Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 83, 85-91

Pelargonidin Improves Memory Deficit in Amyloid β25-35 Rat Model of Alzheimer's Disease by Inhibition of Glial Activation, Cholinesterase, and Oxidative Stress

Affiliations

Pelargonidin Improves Memory Deficit in Amyloid β25-35 Rat Model of Alzheimer's Disease by Inhibition of Glial Activation, Cholinesterase, and Oxidative Stress

Hamid Sohanaki et al. Biomed Pharmacother.

Abstract

Alzheimer's disease (AD) is a multifactorial disorder with devastating outcomes and few mostly palliative available therapeutic strategies. Pelargonidin (Pel), an anthocyanin compound, is an estrogen receptor agonist with lower side effects versus estrogen. This study examined neuroprotective effect of Pel on intrahippocampal amyloid β25-35 (Aβ) rat model of AD. Rats were divided into groups of sham, Aβ, and Pel-pretreated Aβ (10mg/kg; p.o.). Animals underwent Morris water maze (MWM) test in addition to measurement of hippocampal oxidative stress, acetylcholinesterase (AChE) activity, glial fibrillary acidic protein (GFAP) and inducible nitric oxide synthase (iNOS). Pel pretreatment of Aβ group significantly improved escape latency and distance swum in MWM versus Aβ group and attenuated hippocampal malondialdehyde (MDA) and increased catalase activity with no significant change of nitrite. Meanwhile, Pel improved hippocampal AChE activity and lowered GFAP level with no significant change of iNOS. Our results suggest that Pel could improve Aβ25-35-induced memory deficit through mitigation of oxidative stress, cholinergic dysfunction, and astrocyte reaction.

Keywords: Acetylcholinesterase; Glial fibrillary acidic protein; Inducible nitric oxide synthase; Oxidative stress; Pelargonidin; β amyloid.

Similar articles

See all similar articles

Cited by 11 PubMed Central articles

See all "Cited by" articles

MeSH terms

Feedback