Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Sep;9(5):541-8.
doi: 10.1111/1751-7915.12388. Epub 2016 Jul 29.

Antibiotic Drug Discovery

Affiliations
Free PMC article
Review

Antibiotic Drug Discovery

Wolfgang Wohlleben et al. Microb Biotechnol. .
Free PMC article

Abstract

Due to the threat posed by the increase of highly resistant pathogenic bacteria, there is an urgent need for new antibiotics; all the more so since in the last 20 years, the approval for new antibacterial agents had decreased. The field of natural product discovery has undergone a tremendous development over the past few years. This has been the consequence of several new and revolutionizing drug discovery and development techniques, which is initiating a 'New Age of Antibiotic Discovery'. In this review, we concentrate on the most significant discovery approaches during the last and present years and comment on the challenges facing the community in the coming years.

Figures

Figure 1
Figure 1
Approaches in natural product discovery aiming to identify novel antibiotics.

Similar articles

See all similar articles

Cited by 15 articles

See all "Cited by" articles

References

    1. Abdelmohsen U.R, Grkovic T., Balasubramanian S., Kamel M.S., Quinn R.J., and Hentschel U. (2015) Elicitation of secondary metabolism in actinomycetes. Biotechnol Adv 33: 798–811. - PubMed
    1. Allard P.M., Péresse T., Bisson J., Gindro K., Marcourt L., Pham V.C., et al (2016) Integration of molecular networking and in‐silico MS/MS fragmentation for natural products dereplication. Anal Chem 88: 3317–3323. - PubMed
    1. Baltz R.H. (2005) Antibiotic discovery from actinomycetes: will a renaissance follow the decline and fall? SIM News 55: 186–196.
    1. Baltz R.H. (2007) Antimicrobials from actinomycetes: back to the future. Microbe 2: 125–131.
    1. Bandeira N. (2011) Protein identification by spectral networks analysis. Methods Mol Biol 694: 151–168. - PubMed

Publication types

MeSH terms

Feedback