Environmental exposure to endocrine-disrupting chemicals and miscarriage

Fertil Steril. 2016 Sep 15;106(4):941-7. doi: 10.1016/j.fertnstert.2016.06.043. Epub 2016 Jul 26.


Establishment of early pregnancy is the result of complex biochemical interactions between the decidua and blastocyst. Any alteration in this chemical dialogue has the potential to result in adverse pregnancy outcomes including miscarriage. Sporadic miscarriage is the most common complication of pregnancy and can be caused by multiple factors. While the most common cause of miscarriage is genetic abnormalities in the fetus, other contributing factors certainly can play a role in early loss. One such factor is environmental exposure, in particular to endocrine-disrupting chemicals, which has the potential to interfere with endogenous hormone action. These effects can be deleterious, especially in early pregnancy when the hormonal milieu surrounding implantation is in delicate balance. The purpose of this paper is to review the current evidence on the role of environmental toxins in reproduction.

Keywords: Miscarriage; endocrine disrupting chemicals; environment.

Publication types

  • Review

MeSH terms

  • Abortion, Spontaneous / chemically induced*
  • Animals
  • Endocrine Disruptors / adverse effects*
  • Environmental Pollutants / adverse effects*
  • Female
  • Humans
  • Male
  • Pregnancy
  • Reproduction / drug effects*
  • Risk Assessment
  • Risk Factors


  • Endocrine Disruptors
  • Environmental Pollutants