Endothelial progenitor cells participation in cardiovascular and kidney diseases: a systematic review

Acta Biochim Pol. 2016;63(3):475-82. doi: 10.18388/abp.2016_1284. Epub 2016 Jul 30.


Endothelial progenitor cells (EPCs) represent a small population of blood cells (5-40 cells/mm(3)), with an ability to differentiate into endothelial cells that form the lining of the blood vessels and contribute to postnatal angiogenesis. Abundant evidence shows that recruitment of EPCs from the bone marrow, the monocyte/macrophage lineage and the organs facilitate the endothelial regeneration and repair. Changes in the number of EPCs were observed in both, chronic kidney and cardiovascular diseases. Thus, these cells were tested for usage in diagnosis and therapy. In this paper, we review the current knowledge on the EPC biology and contribution of these cells to the kidney and cardiovascular diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / pathology*
  • Cardiovascular Diseases / therapy
  • Endothelial Progenitor Cells / physiology*
  • Humans
  • Kidney Diseases / pathology*
  • Kidney Diseases / therapy
  • Regenerative Medicine