Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles

J Cosmet Dermatol. 2017 Mar;16(1):103-111. doi: 10.1111/jocd.12258. Epub 2016 Jul 29.


Background: Platelet-rich plasma (PRP) is considered as a growing modality for tissue regeneration and a developing research area for clinicians and researchers. PRP injection treatment provides supraphysiological concentrations of growth factors that may help in accelerated tissue remodeling and regeneration.

Aim of the study: To evaluate the efficacy and safety of single autologous PRP intradermal injection for treatment of facial wrinkles and for facial rejuvenation.

Patients and methods: A total of 20 subjects with different types of facial wrinkles were included in this study. All subjects received single PRP intradermal injection and were clinically assessed before and after treatment for a period of 8 weeks using Wrinkle Severity Rating Scale (WSRS), Skin Homogeneity and Texture (SHnT) Scale, Physician Assessment Scale, and Subject Satisfaction Scale.

Results: The mean value of WSRS reduced from 2.90 ± 0.91 before treatment to 2.10 ± 0.79 after 8 weeks of treatment. The most significant results were with younger subjects that have mild and moderate wrinkles of the nasolabial folds (NLFs). Fourteen of seventeen subjects with NLFs showed more than 25% improvement in their appearance. Side effects of PRP treatment were minimal to mild and with excellent tolerability.

Conclusion: Single PRP intradermal injection is well tolerated and capable of rejuvenating the face and producing a significant correction of wrinkles especially the NLFs.

Keywords: anti-aging; facial rejuvenation; platelet-rich plasma; tissue regeneration; wrinkles.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Age Factors
  • Cosmetic Techniques* / adverse effects
  • Female
  • Humans
  • Injections, Intradermal
  • Middle Aged
  • Nasolabial Fold
  • Patient Satisfaction
  • Platelet-Rich Plasma*
  • Regeneration
  • Skin Aging*
  • Treatment Outcome