Hepatocellular carcinoma recurrence pattern following liver transplantation and a suggested surveillance algorithm

Clin Imaging. 2016 Nov-Dec;40(6):1131-1134. doi: 10.1016/j.clinimag.2016.07.002. Epub 2016 Jul 7.


Purpose: This study aims to evaluate the recurrence pattern of hepatocellular carcinoma (HCC) following liver transplantation.

Materials and methods: A total of 54 patients underwent liver transplantation for HCC; 9 patients developed biopsy-proven recurrent HCC (16.6%). The site of HCC recurrence along with other factors was analyzed.

Results: Seven patients were diagnosed with HCC prior to liver transplantation and 2 patients had incidental HCC in the explanted liver. Two patients had locoregional recurrence, 4 patients had distant metastasis, and 3 patients had synchronous locoregional recurrence and distant metastasis.

Conclusion: A significant proportion of HCC recurrence following liver transplantation is extrahepatic.

Keywords: HCC; Hepatocellular carcinoma; Liver transplantation; Metastasis; Surveillance.

MeSH terms

  • Adult
  • Aged
  • Algorithms
  • Carcinoma, Hepatocellular / diagnosis
  • Carcinoma, Hepatocellular / surgery*
  • Female
  • Humans
  • Incidental Findings
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / surgery*
  • Liver Transplantation*
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnosis*
  • Postoperative Complications / diagnosis*
  • Retrospective Studies