Serum vitamin D levels decrease in children with acute urticaria

Allergol Immunopathol (Madr). 2016 Nov-Dec;44(6):512-516. doi: 10.1016/j.aller.2016.04.007. Epub 2016 Jul 28.


Background: Acute urticaria is an immune-inflammatory disease, characterised by acute immune activation. There has been increasing evidence showing that vitamin D deficiency is associated with increased incidence and severity of immune-inflammatory disorders.

Objective: The aim of this study was to evaluate serum vitamin D levels in acute urticaria.

Methods: We enrolled 30 children with acute urticaria and 30 control subjects. Concentrations of 25-hydroxyvitamin D [25(OH)D], a biomarker of vitamin D status, were measured in serum of acute urticaria patients and compared with the control group.

Results: There were no significant differences in baseline variables (age, gender, weight) between the groups. Vitamin D deficiency (<20ng/ml) was significantly higher in patients with acute urticaria than in control patients. Serum 25(OH)D levels were significantly lower in the study group compared to those in the control group (13.1±4.3 vs 28.2±7.4ng/mL, p<0.05). Moreover, we found negative correlation between mean duration of acute urticaria and serum vitamin D levels (p<0.01).

Conclusion: This study revealed a significant association of lower serum 25(OH)D concentrations with acute urticaria and an inverse relationship with disease duration. These findings may open up the possibility of the clinical use of vitamin D as a contributing factor in the pathogenesis of acute urticaria and a predictive marker for disease activity in acute urticaria. A potential role of vitamin D in pathogenesis and additive therapy in acute urticaria needs to be examined.

Keywords: 25-Hydroxyvitamin; Acute urticaria; Allergy; Children; Skin diseases; Urticaria; Vitamin D.

MeSH terms

  • Acute Disease
  • Biomarkers / blood*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Urticaria / diagnosis*
  • Vitamin D / blood*


  • Biomarkers
  • Vitamin D