Hydroxytyrosol modulates Par j 1-induced IL-10 production by PBMCs in healthy subjects

Immunobiology. 2016 Dec;221(12):1374-1377. doi: 10.1016/j.imbio.2016.07.009. Epub 2016 Jul 25.


Several papers have demonstrated the importance of substances from natural sources which can exert powerful anti-inflammatory effects. In this respect, hydroxytyrosol, one of the major elements of the phenolic components of olive oil, has been extensively studied for its anti-inflammatory activities and safety profile. In this report, we demonstrate that the co-stimulation of human PBMCs from healthy subjects with the Par j 1 allergen and hydroxytyrosol induced a statistically significant increase in the amount of Par j 1-induced IL-10, demonstrating that hydroxytyrosol can modulate an allergen-specific immune response potentiating a suppressive immune response towards an allergen. Our work opens the way to further studies to elaborate the possibility of using hydroxytyrosol as a nutrient for allergy prevention.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allergens / immunology
  • Anti-Inflammatory Agents / pharmacology*
  • Antigens, Plant / immunology
  • Cells, Cultured
  • Diet
  • Humans
  • Hypersensitivity / diet therapy*
  • Hypersensitivity / immunology
  • Immunomodulation
  • Interleukin-10 / metabolism
  • Leukocytes, Mononuclear / drug effects*
  • Leukocytes, Mononuclear / immunology
  • Olive Oil
  • Phenylethyl Alcohol / analogs & derivatives*
  • Phenylethyl Alcohol / pharmacology
  • Plant Proteins / immunology
  • Urticaceae / immunology


  • Allergens
  • Anti-Inflammatory Agents
  • Antigens, Plant
  • Olive Oil
  • PMAI protein, Parietaria judaica
  • Plant Proteins
  • 3,4-dihydroxyphenylethanol
  • Interleukin-10
  • Phenylethyl Alcohol