Intratumoral Ethyl Alcohol Injection for Devascularization of Hypervascular Intracranial Tumors

Turk Neurosurg. 2016;26(5):684-9. doi: 10.5137/1019-5149.JTN.13567-14.2.


Aim: Hypervascular intracranial tumors may cause serious bleeding in surgery. Though pre-operative endovascular embolization of tumor is a widely accepted method, sometimes despite embolization, an effective and safer intraoperative hemostatic technique is needed to prevent or at least decrease the massive bleeding from the tumors. The aim of this study was to investigate the effect of the ethyl alcohol (EA) injection in hypervascular tumors and find out whether it is likely to be an alternative method to prevent massive bleeding from tumor.

Material and methods: Fifty-five cases that had hypervascular intracranial tumor and underwent EA injections into their tumors were included in the study. A small amount (0.1-0.2 ml) of EA was used in every injection. Total EA amount differed from 1.2 to 18 ml for each patient.

Results: Most of the tumors were removed with less bleeding, because bleedings stopped or decreased during resection after EA injections. No serious complication that might be related to EA was observed.

Conclusion: EA injection into the tumor is an easy, cheap and less invasive method to obtain effective and safe tumor devascularization. It may be an alternative method for tumor devascularization when preoperative embolization cannot be performed due to any reason or severe bleeding despite embolization.

MeSH terms

  • Adult
  • Aged
  • Blood Loss, Surgical / prevention & control*
  • Brain Neoplasms / blood supply*
  • Ethanol / administration & dosage*
  • Ethanol / pharmacology*
  • Female
  • Humans
  • Injections
  • Male
  • Middle Aged
  • Preoperative Care / methods*
  • Retrospective Studies


  • Ethanol