Filling the (SR)GAP in Excitatory/Inhibitory Balance

Neuron. 2016 Jul 20;91(2):205-7. doi: 10.1016/j.neuron.2016.07.008.

Abstract

In this issue of Neuron, Fossati et al. (2016) report that through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory and inhibitory synapse development, offering a putative evolutionary genetic mechanism for preserving excitatory/inhibitory balance during speciation.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • GTPase-Activating Proteins / genetics*
  • GTPase-Activating Proteins / metabolism
  • Humans
  • Mutation / genetics
  • Neurons / metabolism*
  • Synapses / physiology*

Substances

  • GTPase-Activating Proteins
  • SRGAP3 protein, human
  • rho GTPase-activating protein