Filling the (SR)GAP in Excitatory/Inhibitory Balance

Jaichandar Subramanian; Elly Nedivi

doi:10.1016/j.neuron.2016.07.008

Filling the (SR)GAP in Excitatory/Inhibitory Balance

Neuron. 2016 Jul 20;91(2):205-7. doi: 10.1016/j.neuron.2016.07.008.

Authors

Jaichandar Subramanian¹, Elly Nedivi²

Affiliations

¹ Picower Institute for Learning and Memory, Departments of Biology and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
² Picower Institute for Learning and Memory, Departments of Biology and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: nedivi@mit.edu.

PMID: 27477010
DOI: 10.1016/j.neuron.2016.07.008

Abstract

In this issue of Neuron, Fossati et al. (2016) report that through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory and inhibitory synapse development, offering a putative evolutionary genetic mechanism for preserving excitatory/inhibitory balance during speciation.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
GTPase-Activating Proteins / genetics*
GTPase-Activating Proteins / metabolism
Humans
Mutation / genetics
Neurons / metabolism*
Synapses / physiology*

Substances

GTPase-Activating Proteins
SRGAP3 protein, human
rho GTPase-activating protein