A Powerful DREADD: Revealing Structural Drivers of Functional Dynamics

Ankit N Khambhati; Danielle S Bassett

doi:10.1016/j.neuron.2016.07.011

A Powerful DREADD: Revealing Structural Drivers of Functional Dynamics

Neuron. 2016 Jul 20;91(2):213-5. doi: 10.1016/j.neuron.2016.07.011.

Authors

Ankit N Khambhati¹, Danielle S Bassett²

Affiliations

¹ Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: dsb@seas.upenn.edu.

PMID: 27477013
DOI: 10.1016/j.neuron.2016.07.011

Abstract

In this issue of Neuron, Grayson et al. (2016) report how inhibition of amygdala impacts amygdalocortical and corticocortical functional connectivity. Their study predicts changes in functional brain topology, induced by pharmacologic modulation of neuroanatomical circuits using designer receptors exclusively activated by designer drugs (DREADDs), through virtual lesioning of amygdala in structural brain networks.

Keywords: DREADDs; functional brain network; network neuroscience; structural brain network; virtual lesioning.

Publication types

Review
Comment

MeSH terms

Animals
Behavior / physiology
Brain / physiology*
Computer Simulation*
Humans
Nerve Net / physiology*
Neurons / physiology*
Signal Transduction / physiology*