Micronucleus test with colchicine given by intraperitoneal injection and oral gavage

Mutat Res. 1989 Aug;223(4):391-4. doi: 10.1016/0165-1218(89)90093-1.


The effects of micronucleus induction in mouse bone marrow cells by intraperitoneal injection (i.p.) and oral administration (p.o.) were studied with the spindle poison colchicine in 2 strains of mice (MS/Ae and CD-1). The final micronucleus test was performed with a 24-h sampling time at doses of 0.25-2.0 mg/kg by the i.p. route and 2-16 mg/kg by the p.o. route based on a simple acute toxicity test and a pilot micronucleus experiment. Colchicine induced micronuclei in both strains and at all doses tested. Micronuclei were induced more effectively by the i.p. route.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Animals
  • Colchicine / administration & dosage*
  • Colchicine / toxicity
  • Injections, Intraperitoneal
  • Lethal Dose 50
  • Male
  • Mice
  • Micronucleus Tests*
  • Mutagens / administration & dosage*
  • Pilot Projects


  • Mutagens
  • Colchicine