Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men

Arch Physiol Biochem. 2016 Oct;122(4):167-179. doi: 10.1080/13813455.2016.1202985. Epub 2016 Jul 31.


Context: Insulin resistance and dysglycemia are associated with physical inactivity and adiposity, and may be improved by exercise.

Objective: Investigate the effect of exercise on insulin sensitivity, body composition and adipose depots in sedentary men with (n = 11) or without (n = 11) overweight and dysglycemia.

Material and methods: Euglycemic-hyperinsulinemic clamp, ankle-to-neck MRI, MRS, muscle and adipose tissue biopsies before and after 12 weeks combined strength and endurance exercise.

Results: Insulin sensitivity, VO2max, strength, whole-body and muscle fat content, and abdominal adipose depots were improved without obvious differences between normo- and dysglycemic men. Hepatic fat, waist circumference and subcutaneous adipose tissue were reduced in the dysglycemic group. For both groups plasma adiponectin was reduced, whereas IL-6 was unchanged. Visceral fat was preferentially lost compared with other adipose depots.

Discussion and conclusion: Body composition, fat distribution and insulin sensitivity improved following training in sedentary middle-aged men with and without dysglycemia.

Keywords: Adipokines; muscle fat; myokines; prediabetes; visceral fat.

Publication types

  • Comparative Study

MeSH terms

  • Adiposity*
  • Adult
  • Aged
  • Body Composition*
  • Case-Control Studies
  • Exercise*
  • Humans
  • Hyperglycemia / physiopathology*
  • Hypoglycemia / physiopathology*
  • Insulin Resistance*
  • Male
  • Middle Aged
  • Resistance Training*