PIMADb: A Database of Protein-Protein Interactions in Huge Macromolecular Assemblies

Bioinform Biol Insights. 2016 Jul 19:10:105-9. doi: 10.4137/BBI.S38416. eCollection 2016.


Protein-protein interactions play a very important role in the process of cellular functionality. Intricate details about the interactions between the proteins in a macromolecular assembly are important to understand the function and significance of protein complexes. We are reporting about a database of protein-protein interactions in huge macromolecular assemblies (PIMADb) that records the intrinsic details of 189,532 interchain interactions in 40,049 complexes from the Protein Data Bank. These details include the results of the quantification and analysis of all the interactions in the complex. The availability of interprotomer interaction networks can enable the design of point mutation experiments. PIMADb can be accessed from the URL: http://caps.ncbs.res.in/pimadb.

Keywords: interface residues; macromolecule; protein assembly; protein-protein interaction.