Relationship between rotational behaviour induced by apomorphine and caffeine in rats with unilateral lesion of the nigrostriatal pathway

Neuropharmacology. 1989 Apr;28(4):407-9. doi: 10.1016/0028-3908(89)90037-3.

Abstract

The contralateral rotational behaviour produced by apomorphine and caffeine has been studied in 100 rats with unilateral lesion of the nigrostriatal pathway induced with 6-OHDA. Rats with a two-peak rotational pattern induced by apomorphine, showed a greater number of contralateral turns, induced by apomorphine and caffeine, than rats which did not show this rotational pattern. A correlation was observed between the number of rotations induced by apomorphine and those induced by caffeine. A relationship between the two-peak rotational pattern induced by apomorphine and the initial-peak pattern induced by caffeine was also observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apomorphine / pharmacology*
  • Caffeine / pharmacology*
  • Corpus Striatum / physiology*
  • Male
  • Neural Pathways / physiology*
  • Rats
  • Rats, Inbred Strains
  • Stereotyped Behavior / drug effects*
  • Substantia Nigra / physiology*

Substances

  • Caffeine
  • Apomorphine