Subclinical Hypothyroidism in PCOS: Impact on Presentation, Insulin Resistance, and Cardiovascular Risk

Biomed Res Int. 2016;2016:2067087. doi: 10.1155/2016/2067087. Epub 2016 Jul 12.


Aim of Study. To assess status of thyroid function and thyroid disorders particularly subclinical hypothyroidism (SCH) in subjects with polycystic ovarian syndrome (PCOS) and impact of SCH on various clinical and biochemical parameters and cardiovascular risk in PCOS. Methods. Hundred females diagnosed with PCOS as per Rotterdam criteria and 100 normal controls were recruited and were subjected to elaborate anthropometric, clinical, and biochemical assessment. Results. Notable findings included significantly higher frequency of subjects with subclinical hypothyroidism (p = 0.0002), autoimmune thyroiditis (p < 0.001), and goitre (p = 0.02) in polycystic ovarian syndrome subjects compared to control subjects. Further SCH PCOS subjects were found to harbor significantly higher HOMA-IR (p < 0.05) and frequency of subjects with dyslipidemia (p < 0.05) compared to both euthyroid PCOS and euthyroid control subjects. Though frequency of subjects with cardiovascular risk factors was higher in SCH PCOS group than euthyroid PCOS group, it failed to reach statistical significance. Conclusion. We concluded that PCOS is associated with high incidence of SCH and AIT compared to normal population and SCH poses increased risk of cardiovascular disorder in PCOS.

MeSH terms

  • Adolescent
  • Adult
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / physiopathology*
  • Female
  • Goiter / complications
  • Goiter / physiopathology
  • Hirsutism / complications
  • Hirsutism / physiopathology
  • Humans
  • Hypothyroidism / blood
  • Hypothyroidism / complications
  • Hypothyroidism / physiopathology*
  • Insulin Resistance*
  • Middle Aged
  • Polycystic Ovary Syndrome / complications
  • Polycystic Ovary Syndrome / physiopathology*
  • Risk Factors
  • Thyroiditis, Autoimmune / complications
  • Thyroiditis, Autoimmune / physiopathology