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. 2016 Sep;26(9):1156-66.
doi: 10.1089/thy.2016.0064. Epub 2016 Aug 23.

Management of Invasive Differentiated Thyroid Cancer

Free PMC article

Management of Invasive Differentiated Thyroid Cancer

Iain J Nixon et al. Thyroid. .
Free PMC article


Background: Invasive disease is a poor prognostic factor for patients with differentiated thyroid cancer (DTC). Uncontrolled central neck disease is a common cause of distressing death for patients presenting in this manner. Advances in assessment and management of such cases have led to significant improvements in outcome for this patient group. This article reviews the patterns of invasion and a contemporary approach to investigation and treatment of patients with invasive DTC.

Summary: Aerodigestive tract invasion is reported in around 10% of case series of DTC. Assessment should include not only clinical history and physical examination with endoscopy as indicated, but ultrasound and contrast-enhanced cross-sectional imaging. Further studies including positron emission tomography should be considered, particularly in recurrent cases that are radioactive iodine (RAI) resistant. Both the patient and the extent of disease should be carefully assessed prior to embarking on surgery. The aim of surgery is to resect all gross disease. When minimal visceral invasion is encountered early, "shave" procedures are recommended. In the setting of transmural invasion of the airway or esophagus, however, full thickness excision is required. For intermediate cases in which invasion of the viscera has penetrated the superficial layers but is not evident in the submucosa, opinion is divided. Early reports recommended an aggressive approach. More recently authors have tended to recommend less aggressive resections with postoperative adjuvant therapies. The role of external beam radiotherapy continues to evolve in DTC with support for its use in patients considered to have RAI-resistant tumors.

Conclusions: Patients with invasive DTC require a multidisciplinary approach to investigation and treatment. With detailed assessment, appropriate surgery, and adjuvant therapy when indicated, this patient group can expect durable control of central neck disease, despite the aggressive nature of their primary tumors.

Conflict of interest statement

Author Disclosure Statement Dr. Kate Newbold has consultancy and advisory roles with Eisai, Astra-Zeneca, and Genzyme. The other authors have nothing to disclose.


<b>FIG. 1.</b>
FIG. 1.
Classification of tracheal invasion as proposed by Shin et al. (18) (courtesy of Memorial Sloan Kettering Cancer Center).
<b>FIG. 2.</b>
FIG. 2.
Schematic of disease invading posteriorly into the paraglottic space (courtesy of Memorial Sloan Kettering Cancer Center).
<b>FIG. 3.</b>
FIG. 3.
Computed tomography (CT) scan showing recurrent papillary thyroid cancer invading in to pyriform fossa at level of cricoid cartilage.
<b>FIG. 4.</b>
FIG. 4.
Endoscopic image of same patient under general anesthetic with disease evidence in the hypopharynx.
<b>FIG. 5.</b>
FIG. 5.
Schematic of esophageal invasion (courtesy of Memorial Sloan Kettering Cancer Center).
<b>FIG. 6.</b>
FIG. 6.
Primary disease encases the left recurrent laryngeal nerve at the level of the tubercle of Zuckerkandl.
<b>FIG. 7.</b>
FIG. 7.
Metastatic lymph nodes encasing the recurrent laryngeal nerve.
<b>FIG. 8.</b>
FIG. 8.
Schematic of invasion of the recurrent laryngeal nerve by primary disease (courtesy of Memorial Sloan Kettering Cancer Center).
<b>FIG. 9.</b>
FIG. 9.
Disease involving the muscular layer of the esophagus. The muscularis layer of the esophagus is usually very resistant to invasion.

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