Complete genome sequence of Lactobacillus plantarum LZ227, a potential probiotic strain producing B-group vitamins

J Biotechnol. 2016 Sep 20:234:66-70. doi: 10.1016/j.jbiotec.2016.07.020. Epub 2016 Jul 29.


B-group vitamins play an important role in human metabolism, whose deficiencies are associated with a variety of disorders and diseases. Certain microorganisms such as Lactic acid bacteria (LAB) have been shown to have capacities for B-group vitamin production and thus could potentially replace chemically synthesized vitamins for food fortification. A potential probiotic strain named Lactobacillus plantarum LZ227, which was isolated from raw cow milk in this study, exhibits the ability to produce B-group vitamins. Complete genome sequencing of LZ227 was performed to gain insights into the genetic elements involved in B-group vitamin production. The genome of LZ227 contains a circular 3,131,750-bp chromosome, three circular plasmids and two predicted linear plasmids. LZ227 also contains gene clusters for biosynthesis of both riboflavin and folate. This genome sequence provides a basis for further elucidation of its molecular genetics and probiotic functions, and will facilitate its applications as starter cultures in food industry.

Keywords: B-group vitamins; Complete genome sequence; Folate; L. plantarum LZ227; Riboflavin.

MeSH terms

  • Animals
  • Cattle
  • Chromosome Mapping
  • Folic Acid / biosynthesis*
  • Genome, Bacterial*
  • Lactobacillus plantarum / classification
  • Lactobacillus plantarum / genetics*
  • Lactobacillus plantarum / metabolism
  • Phylogeny
  • Probiotics
  • Riboflavin / biosynthesis*
  • Vitamin B Complex / biosynthesis*


  • Vitamin B Complex
  • Folic Acid
  • Riboflavin