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. 2016 Aug 23;115(5):592-8.
doi: 10.1038/bjc.2016.232. Epub 2016 Aug 2.

De Novo Post-Diagnosis Statin Use, Breast Cancer-Specific and Overall Mortality in Women With Stage I-III Breast Cancer

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Free PMC article

De Novo Post-Diagnosis Statin Use, Breast Cancer-Specific and Overall Mortality in Women With Stage I-III Breast Cancer

Amelia Smith et al. Br J Cancer. .
Free PMC article

Abstract

Background: Prior evidence suggests a role for statins in the management of cancer. However, the benefit of statin use in the adjuvant setting remains uncertain. This study investigates associations between statin use initiated after a breast cancer diagnosis and mortality.

Methods: Women with stage I-III breast cancer were identified from the National Cancer Registry of Ireland (N=4243). Post-diagnostic statin initiators were identified from pharmacy claims data (N=837). Multivariate models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between de novo statin use and mortality.

Results: The median duration of statin use was 6.7 years. No association was found between post-diagnostic statin use and breast cancer-specific (HR 0.88, 95% CI 0.66, 1.17) or all-cause mortality (HR 1.00, 95% CI 0.82, 1.21).

Conclusions: The results from our study suggest that initiating statin use after a diagnosis of stage I-III breast cancer is not associated with a reduction in breast cancer-specific mortality.

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