Cytotoxicity of isoquinoline alkaloids and their N-oxides

Planta Med. 1989 Apr;55(2):163-5. doi: 10.1055/s-2006-961913.


A series of 53 isoquinoline alkaloids and their N-oxides have been tested for their cytotoxicity against A-549, HCT-8, KB, P-388, and L-1210 cells. These alkaloids include two tetrahydroprotoberberines, two protoberberines, six aporphines, one morphinandienone, five oxoaporphines, seven phenanthrenes, one spirobenzylisoquinoline N-oxide, nine aporphine N-oxides, seven benzyltetrahydroisoquinoline N-oxides, one benzylisoquinoline N-oxide, one protopine N-oxide, three tetrahydroprotoberberine N-oxides, four pavine N-oxides, and four phenanthrene N-oxides. The results are discussed on the basis of structure-activity relationships.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alkaloids / pharmacology*
  • Animals
  • Antineoplastic Agents, Phytogenic*
  • Cell Line
  • Humans
  • Isoquinolines / pharmacology*
  • Oxides
  • Plants / analysis*
  • Structure-Activity Relationship


  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Isoquinolines
  • Oxides